abstract：:Betel quid, cigarettes and alcohol are well-recognized risk factors for oral cancer. However, the combined effect of the frequency and duration of these oral habits on the risk for developing oral pre-malignancies among betel quid users has not been fully addressed. In this study, an oral screening programme for men c...

journal_title：Oral oncology

authors： Yen AM,Chen SC,Chen TH

更新日期：2007-08-01 00:00:00

abstract：:We demonstrated the accumulation of CD11b(high)Gr-1(+) cells in a murine model of squamous cell carcinoma (SCC). Inoculation of NR-S1K cells derived from oral SCC induced a rapid and clear accumulation of CD11b(high)Gr-1(+) cells in secondary lymphoid organs as well as in peripheral blood. Phenotypic and morphological...

journal_title：Oral oncology

authors： Tanaka K,Jinhua P,Omura K,Azuma M

更新日期：2007-07-01 00:00:00

abstract：:The epidemiological link between human papillomavirus (HPV) DNA and basaloid squamous cell carcinoma (BSCC) of the pharynx was studied. The expression of p53 protein was evaluated by immunohistochemical analysis. The presence of HPV DNA was evaluated by polymerase chain reaction amplification and "in situ" hybridizati...

journal_title：Oral oncology

authors： Cabanillas R,Rodrigo JP,Ferlito A,Rinaldo A,Fresno MF,Aguilar C,Alvarez ME,Suárez C

更新日期：2007-04-01 00:00:00

abstract：:To examine the influence of smoking on observer based morbidity scores and patient assessed health related quality of life after treatment for head and neck cancer. The results of EORTC C30 and H&N35 questionnaires and DAHANCA morbidity scores were studied according to smoking status in 114 recurrence free head and ne...

journal_title：Oral oncology

authors： Jensen K,Jensen AB,Grau C

更新日期：2007-02-01 00:00:00

abstract：:Salivary gland carcinomas are a rare and clinically diverse group of neoplasms among which mucoepidermoid carcinomas (MEC) are reported to be the most frequently encountered. During the years 1994-2004 18 patients with MEC were treated in our Department. All patients underwent surgery with a curative intent, and in 11...

journal_title：Oral oncology

authors： Rapidis AD,Givalos N,Gakiopoulou H,Stavrianos SD,Faratzis G,Lagogiannis GA,Katsilieris I,Patsouris E

更新日期：2007-02-01 00:00:00

abstract：:Chromosomal aberrations are known to have an impact on the initiation and progression of oral squamous cell carcinoma (OSCC), but individual genes involved in OSCC pathogenesis are poorly described. To elucidate the molecular events underlying oral carcinogenesis, a set of primary OSCC were screened for distinct genet...

journal_title：Oral oncology

authors： Freier K,Schwaenen C,Sticht C,Flechtenmacher C,Mühling J,Hofele C,Radlwimmer B,Lichter P,Joos S

更新日期：2007-01-01 00:00:00

abstract：:The aim of this paper is to assess the reproducibility of a novel binary grading system (high/low risk) of oral epithelial dysplasia and to compare it with the WHO classification 2005. The accuracy of the new system for predicting malignant transformation was also assessed. Ninety-six consecutive oral epithelial dyspl...

journal_title：Oral oncology

authors： Kujan O,Oliver RJ,Khattab A,Roberts SA,Thakker N,Sloan P

更新日期：2006-11-01 00:00:00

abstract：:Despite many advances in surgical techniques, technology, radiation therapy, and chemotherapy, survival rates for head and neck cancer (HNCa) have not improved significantly in decades, with many patients being diagnosed at advanced disease stages. Adequate assessment of oral cavity malignancies is critical for approp...

journal_title：Oral oncology

authors： Rumboldt Z,Day TA,Michel M

更新日期：2006-10-01 00:00:00

abstract：:Epidemiological studies showed that stopping smoking substantially decreases the risk of lung cancer. With reference to laryngeal cancer, at least four cohort studies and 15 case-control studies reported information on smoking cessation. These studies indicated that the risk of laryngeal cancer is considerably reduced...

journal_title：Oral oncology

authors： Bosetti C,Garavello W,Gallus S,La Vecchia C

更新日期：2006-10-01 00:00:00

abstract：:The aim of this study was to determine the survival rate of oral cancer patients treated in a medical center in central Taiwan and to investigate whether socio-demographic factors influence their survival. We retrospectively reviewed 1010 chart records of oral cancer patients. Survival was analyzed by the Kaplan-Meier...

journal_title：Oral oncology

authors： Wong YK,Tsai WC,Lin JC,Poon CK,Chao SY,Hsiao YL,Chan MY,Cheng CS,Wang CC,Wang CP,Liu SA

更新日期：2006-10-01 00:00:00

abstract：:Radiation-induced xerostomia can result in the rapid onset and progression of dental caries in head and neck cancer patients. Topically applied fluorides have been successfully used to inhibit the formation of dental caries in this population. However, because intensive daily self-application is required, compliance i...

journal_title：Oral oncology

authors： Chambers MS,Mellberg JR,Keene HJ,Bouwsma OJ,Garden AS,Sipos T,Fleming TJ

更新日期：2006-10-01 00:00:00

abstract：:The concept of dysplasia/neoplasia surveillance has been applied to long-standing conditions associated with an increased risk of cancer. Although still controversial, periodic direct clinical examination as well as endoscopic techniques are currently performed in patients with inflammatory bowel diseases, Barrett's e...

journal_title：Oral oncology

authors： Mignogna MD,Fedele S,Lo Russo L

更新日期：2006-09-01 00:00:00

abstract：:Eosinophils are present in large numbers in some squamous cell carcinomas of the oral cavity. Whilst it is proposed that they have an 'immuno-protective' effect, this remains unproven. The contradictory reports may be due to inconsistencies in eosinophil counting. Eighty-one cases of squamous cell carcinoma (SSC) of o...

journal_title：Oral oncology

authors： Alkhabuli JO,High AS

更新日期：2006-09-01 00:00:00

abstract：:Tumor microcirculatory characteristics until now have only been assessed by histological examination of biopsies or invasive imaging technique. The recent introduction of orthogonal polarization spectral (OPS) imaging as a new tool for in vivo visualization of human microcirculation makes it possible to acquire high r...

journal_title：Oral oncology

authors： Lindeboom JA,Mathura KR,Ince C

更新日期：2006-07-01 00:00:00

abstract：:Yeasts that are resistant to azole antifungal drugs are increasingly isolated from the mouths of cancer patients suffering from oral fungal infections. Tea tree oil is an agent possessing antimicrobial properties that may prove useful in the prevention and management of infections caused by these organisms. In this st...

journal_title：Oral oncology

authors： Bagg J,Jackson MS,Petrina Sweeney M,Ramage G,Davies AN

更新日期：2006-05-01 00:00:00

abstract：:The aim of this study was to define the appropriate fractionation interval between photodynamic therapies (PDTs) for enhanced anti-tumour effects on human oral squamous cell carcinoma (HOSCC). Reoxygenation of HOSCC and the proliferative kinetics of the tumour cells following PDT exposure were evaluated in terms of im...

journal_title：Oral oncology

authors： Togashi H,Uehara M,Ikeda H,Inokuchi T

更新日期：2006-05-01 00:00:00

abstract：:A better understanding of oral cancer pathogenesis is essential to improving patient prognosis and treatment modalities. Research has shown a significant increase in vascularity during the transition from normal oral mucosa, through differing degrees of dysplasia, to invasive carcinoma. A close association between tum...

journal_title：Oral oncology

authors： Johnstone S,Logan RM

更新日期：2006-04-01 00:00:00

abstract：:Osteoprotegerin (OPG) is a useful receptor in inhibiting Receptor Activator of NFkappaB Ligand (RANKL) in inducing osteoclastogenesis. Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) is a potent apoptosis-inducing ligand in ameloblastomas. Since OPG has been reported to bind to TRAIL as well, the...

journal_title：Oral oncology

authors： Sandra F,Hendarmin L,Nakamura S

更新日期：2006-04-01 00:00:00

abstract：:The detection of distant metastases and second primary tumours at the time of initial evaluation changes the prognosis and influences the selection of treatment modality in patients with HNSCC. Until recently chest CT was the single most effective test to screen for distant metastases in HNSCC patients. In this observ...

journal_title：Oral oncology

authors： Brouwer J,Senft A,de Bree R,Comans EF,Golding RP,Castelijns JA,Hoekstra OS,Leemans CR

更新日期：2006-03-01 00:00:00

abstract：:It has been reported that cyclooxygenase-2 (COX-2) plays roles in cell proliferation, tumor invasion and inhibition of apoptosis. We reported COX-2 expression in salivary adenoma and its involvement in inhibition of apoptosis. COX-2 is known to induce a number of cytokines and growth factors. On the other hand, hepato...

journal_title：Oral oncology

authors： Aoki T,Tsukinoki K,Kurabayashi H,Sasaki M,Yasuda M,Ota Y,Watanabe Y,Kaneko A

更新日期：2006-01-01 00:00:00

abstract：:To define the role of surgical management of lung metastases in ACC. Twenty ACC patients referred to lung metastasectomy were retrospectively reviewed. Twenty-six operations were performed; at the first metastasectomy, a resection with clear margins (R0) was achieved in 11 patients (55%), 3 are alive and well. Four ou...

journal_title：Oral oncology

authors： Locati LD,Guzzo M,Bossi P,Massone PP,Conti B,Fumagalli E,Bareggi C,Cantù G,Licitra L

更新日期：2005-10-01 00:00:00

abstract：:Although the amelogenin gene is expressed in ameloblastoma, the precise expression pattern of X and Y amelogenin genes (AMGX, AMGY) in this tumor has not yet been identified. In this study, we analyzed amelogenin gene expression in 19 samples (9 male, 10 female) of oral ameloblastomas by RT-PCR and detect the chromoso...

journal_title：Oral oncology

authors： Tsujigiwa H,Nagatsuka H,Han PP,Gunduz M,Siar CH,Oida S,Nagai N

更新日期：2005-09-01 00:00:00

abstract：:Adenomatoid Odontogenic Tumour (AOT) is a relatively uncommon odontogenic lesion and few studies describing its cytokeratin profile have been reported in the English-language literature. Thirty-nine cases of AOT from three Oral Diagnosis services (Brazil, Mexico and Guatemala) were studied, considering their clinical,...

journal_title：Oral oncology

authors： Leon JE,Mata GM,Fregnani ER,Carlos-Bregni R,de Almeida OP,Mosqueda-Taylor A,Vargas PA

更新日期：2005-09-01 00:00:00

abstract：:ICAM-5 (telencephalin) is an intercellular adhesion molecule reported to be expressed only in the somatodendritic membrane of telencephalic neurons. We recently identified high ICAM-5 expression in a cDNA array study of head and neck neoplasms with a propensity for perineural invasion. To determine the association of ...

journal_title：Oral oncology

authors： Maruya SI,Myers JN,Weber RS,Rosenthal DI,Lotan R,El-Naggar AK

更新日期：2005-07-01 00:00:00

abstract：:CD40 is expressed on basal keratinocytes and Squamous Cell Cancer of the Head and Neck (SCCHN) tumor cells in vivo and in vitro. CD40 ligation reduces proliferation of SCCHN cell lines and enhances EGFr mediated inhibition of proliferation. We investigated the mechanisms of CD40 function and EGFr cross-communication i...

journal_title：Oral oncology

authors： Cao W,Cavacini LA,Tillman KC,Posner MR

更新日期：2005-05-01 00:00:00

abstract：:The presence of distant metastasis after the initial treatment of head and neck squamous cell carcinoma is not considered a common event and is associated with a poor outcome. The objective of this study was to investigate the prevalence and risk factors associated with the diagnosis of distant metastasis in oral and ...

journal_title：Oral oncology

authors： Kowalski LP,Carvalho AL,Martins Priante AV,Magrin J

更新日期：2005-05-01 00:00:00

abstract：:We have investigated whether Ginkgo biloba extract (EGb 761) induces apoptosis of oral cavity cancer cells and attempted to characterize the apoptotic pathway activated by EGb 761. The inhibition of SCC 1483 oral cavity cancer cells proliferation was noted from 250 micro/ml of EGb 761. Apoptosis was observed after 24 ...

journal_title：Oral oncology

authors： Kim KS,Rhee KH,Yoon JH,Lee JG,Lee JH,Yoo JB

更新日期：2005-04-01 00:00:00

abstract：:Seventeen oral squamous cell carcinoma (SCC) patients underwent chemotherapy with TS-1 (8 males and 9 females, mean age; 75.1 years, range; 47-102 years). TS-1 permitted five cases of oral chemotherapy on an outpatient basis and 8 cases in elder patients over 80-years of age. Excepting five patients who underwent TS-1...

journal_title：Oral oncology

authors： Obara S,Yamamoto K,Hosogai N,Yoshimura Y

更新日期：2005-03-01 00:00:00

abstract：:We analyzed the T cell receptor (TCR) gammadelta gene repertoire in peripheral blood and tumor compartment of oral cancer (OC) patients before and after stimulation with heat shock proteins (hsp), which are known ligands for gammadelta T cells. Clonal TCR gamma and delta gene rearrangements in lymphocytes from tumor c...

journal_title：Oral oncology

authors： Wadia P,Atre N,Pradhan T,Mistry R,Chiplunkar S

更新日期：2005-02-01 00:00:00

abstract：:Screening populations for the early detection of asymptomatic malignancies and potential malignancies are intuitively attractive strategies to control or reduce the burden of oral cancer on society. Subsequent preventive and/or therapeutic measures must, however, be substantiated by prospective randomized controlled t...

journal_title：Oral oncology

authors： Lavelle CL,Scully C

更新日期：2005-01-01 00:00:00

abstract：:ED-B fibronectin (ED-B FN), a glycoprotein involved in cell adhesion and migration, is expressed in fetal and neoplastic tissues and absent in their normal counterparts. The aim of this study is to evaluate the expression of this glycoprotein in relation to the histological and clinical data and to determine whether i...

journal_title：Oral oncology

authors： Mhawech P,Dulguerov P,Assaly M,Ares C,Allal AS

更新日期：2005-01-01 00:00:00

abstract：:Lip cancer is the most frequent malignant neoplasm of the oral cavity; however, there is no information available on the incidence of this type of cancer in Mexico. This study provides information about the clinico-pathological features of lip cancer patients admitted at a cancer hospital in Mexico City during an 11-y...

journal_title：Oral oncology

authors： Luna-Ortiz K,Güemes-Meza A,Villavicencio-Valencia V,Mosqueda-Taylor A

更新日期：2004-11-01 00:00:00

abstract：:To encourage the public to attend and accept oral cancer screening, further understanding is required of the ability of structured information to alter patient knowledge and risk perceptions. Previous work has shown the benefit of written information for those at high risk of oral cancer, especially for tobacco smoker...

journal_title：Oral oncology

authors： Humphris GM,Freeman R,Clarke HM

更新日期：2004-10-01 00:00:00

abstract：:Merkel cell carcinoma (MCC) is a rare neuroendocrine neoplasm of the skin. The tumor most frequently affects elderly patients, with a preference for the head and neck. Incidence rates increase with sun exposure and after immunosuppression and organ transplantation. A significant proportion of MCC have been reported to...

journal_title：Oral oncology

authors： Suárez C,Rodrigo JP,Ferlito A,Devaney KO,Rinaldo A

更新日期：2004-09-01 00:00:00

abstract：:Proliferative verrucous leukoplakia (PVL) is a very aggressive form of oral leukoplakia (OL) with high morbidity and mortality rates, hypothesised to be linked to HPV infection. This study aimed to determine the presence of HPV DNA in PVL in comparison with OL, and in relation to social-demographical variables (age, g...

journal_title：Oral oncology

authors： Campisi G,Giovannelli L,Ammatuna P,Capra G,Colella G,Di Liberto C,Gandolfo S,Pentenero M,Carrozzo M,Serpico R,D'Angelo M

更新日期：2004-09-01 00:00:00

abstract：:The mitogen activated serine/threonine kinases (MAPKs) constitute extracellular signal-regulated protein kinases (ERKs), c-Jun N-terminal kinases (JNKs) and p38 MAPK, with an important role in cell proliferation and transformation. Earlier studies from our laboratory had indicated a role for MAPK pathway in oral cance...

journal_title：Oral oncology

authors： Rai R,Mahale A,Saranath D

更新日期：2004-08-01 00:00:00

abstract：:Oral cancer models have attempted to demonstrate inhibition of oral carcinogenesis. These models used synthetic carcinogens, lacked a specific mechanism of activity or used non-physiologic doses for carcinogen or inhibitor. To correct these problems the tobacco and environmental carcinogen, dibenzo[a,l]pyrene (DB[a,l]...

journal_title：Oral oncology

authors： Schwartz J,Baker V,Larios E,Desai D,Amin S

更新日期：2004-07-01 00:00:00

abstract：:We investigated the knowledge and behaviors of a random sample of 500 primary care physicians (PCPs) regarding oral cancer in Calabria (Italy). 87.6% and 64% indicated tobacco and alcohol use as risk factors, only 31.5% and 2.8% having a prior oral cancer lesion and older age. 60.9% knew that squamous-cell carcinoma i...

journal_title：Oral oncology

authors： Nicotera G,Di Stasio SM,Angelillo IF

更新日期：2004-05-01 00:00:00

abstract：:Squamous cell carcinoma of the pharynx and larynx (SCCPL) is a genetically complex disease and is frequently associated with nonrandom chromosomal alterations. Fifty primary SCC of the pharynx (oropharynx, n=11): see and hypopharynx, n=11) and larynx ( n=28) were examined for numerical aberrations of chromosomes 8, 9,...

journal_title：Oral oncology

authors： Hardisson D,Alvarez-Marcos C,Salas-Bustamante A,Alonso-Guervós M,Sastre N,Sampedro A

更新日期：2004-04-01 00:00:00

abstract：:Squamous cell carcinoma of the oral cavity (SCC) accounts for 3% of cancers in the western world and 40% of cancers in India. The overall 5-year survival rate is only 50%. Most of the lesions appear intra-orally on the tongue. Results from a previous study demonstrated a significant increase in T and B-lymphocytes und...

journal_title：Oral oncology

authors： Gannot G,Buchner A,Keisari Y

更新日期：2004-03-01 00:00:00